Certain drugs and alcohol can affect how your body processes the medication, which can alter its effects. Mixing antidepressants with alcohol or other drugs. For the best results, be sure to follow all directions. The medication bottle may also say that you should take the antidepressant with food or avoid certain foods. Take the amount prescribed, and take the medication at the recommended time of day. Make sure you follow all directions on your medication bottle. Not taking the medication the way it is prescribed. Common reasons why they may stop working include: What are common reasons why antidepressants don’t work?Īntidepressants may not work as effectively for a number of different reasons. We may receive compensation when a user decides to leverage these services, but making them available does not influence the medical content our editorial staff provides. We also provide access to services offered by GoodRx and our partners when we think these services might be useful to our visitors. See our editorial policy for more detail. GoodRx Health information and resources is reviewed by our editorial staff with medical and healthcare policy and pricing experience. But in general, it can take 6 to 8 weeks to feel the effects. The length of time it takes for antidepressants to start working varies from person to person. These medications are often prescribed when a person has not benefited from other antidepressants or experienced negative side effects. Tricyclics, which include amitriptyline (Elavil), imipramine (Tofranil), and clomipramine (Anafranil), are similar to SNRIs in that they block the reabsorption of serotonin and norepinephrine into nerve cells.Ītypical antidepressants, like bupropion (Wellbutrin), trazodone (Desyrel), and mirtazapine (Remeron), alter levels of serotonin, dopamine, and norepinephrine in the brain in different ways than other types of antidepressants. MAOIs stop the effects of the monoamine oxidase enzyme, which breaks down these chemicals. Monoamine oxidase inhibitors (MAOIs), like tranylcypromine (Parnate) and phenelzine (Nardil), increase levels of dopamine, serotonin, and norepinephrine in the brain. Serotonin and norepinephrine reuptake inhibitors (SNRIs), including venlafaxine (Effexor) and duloxetine (Cymbalta), stop the reabsorption of serotonin and norepinephrine into nerve cells, which increases the amount of these chemicals in the brain. This action allows more serotonin to be available in the brain. They do this by stopping the reabsorption of serotonin back into nerve cells. Selective serotonin reuptake inhibitors (SSRIs), like sertraline (Zoloft), fluoxetine (Prozac), and escitalopram (Lexapro), increase levels of a neurotransmitter called serotonin. There are 4 main types of antidepressants: These changes are believed to help improve mood and reduce depression and anxiety. Antidepressants work by changing levels of certain chemicals in the brain called neurotransmitters.
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